Our speakers travel from across the globe to present at the meeting. They are each working ‘at the limits’ of research and understanding and we ask them to share their unique insights in engaging and innovative ways. The unique format of the meeting, with strictly limited delegate numbers means we have ample time for Q&A and delegates have a great opportunity to question our experts in depth. The discussion and debate is often passionate and challenging and the live peer review in quite unlike any of the major annual conventions. Importantly we are eager to enable the maximum spread of the scientific knowledge and we make each presentation available shortly after the event on the ‘atthelimits.org’ and ‘lancet.com’ websites.